Chimeric Autologous/Allogeneic Constructs for Skin Regeneration
نویسندگان
چکیده
منابع مشابه
Chimeric composite skin substitutes for delivery of autologous keratinocytes to promote tissue regeneration.
OBJECTIVE We hypothesize that the pathogen-free NIKS human keratinocyte progenitor cell line cultured in a chimeric fashion with patient's primary keratinocytes would produce a fully stratified engineered skin substitute tissue and serve to deliver autologous keratinocytes to a cutaneous wound. SUMMARY OF BACKGROUND DATA Chimeric autologous/allogeneic bioengineered skin substitutes offer an i...
متن کاملBiomask for skin regeneration.
Critical challenges in facial skin wound healing The use of helmets and body armor in mod ern warfare greatly reduces the mortality and severity of injury for soldiers. However, facial injuries resulting from improvised explosive devices (IEDs), gun shots and burns are still common. Based on data from the Joint Theater Trauma Registry, craniomaxillo facial battle injuries to the head and neck...
متن کاملBioprinting of skin constructs for wound healing
Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the ...
متن کاملTissue engineered fetal skin constructs for pediatric burns
Autologous skin-grafting is the gold standard for treatment of deep second and third degree burns. Available bioengineered skin products also necessitate this two-step surgical procedure. Therefore, we developed fetal skin constructs to improve healing of such degree burns. A bank of fetal skin cells was developed from one organ donation (4 cm2 of skin allowing the preparation of several millio...
متن کاملStem Cell Niches for Skin Regeneration
Stem cell-based therapies offer tremendous potential for skin regeneration following injury and disease. Functional stem cell units have been described throughout all layers of human skin and the collective physical and chemical microenvironmental cues that enable this regenerative potential are known as the stem cell niche. Stem cells in the hair follicle bulge, interfollicular epidermis, derm...
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ژورنال
عنوان ژورنال: Military Medicine
سال: 2014
ISSN: 0026-4075,1930-613X
DOI: 10.7205/milmed-d-13-00480